He had no medical problems before this, and I took him to the vet every year he ended up dying two weeks later , I took him to the vet first they told me he wasnt gonna make it to leave him there and I told him no if he isnt gonna make it, hes going to pass away in my arms at home with me and his family why took him to a different vet not the same one I confronted the woman that gave me that medicine. He is my first dog, he is 5yrs old now, and this is all new. I will keep a close eye on him and hopefully nothing else come about, we will NEVER take this medication again! He looked like he was having a seizure. No more of this med! By overloading chloride into these worms, it affects the electrical activity within their nervous system, causing muscle paralysis and death. . Took to vet and she said it could be the Simparico Trio. This is because it doesn't kill adult heartworms. How did your baby do please? Around 9pm he was barely able to jump up onto the couch and was extremely hesitant to go up the steps. Will be talking to the vet inregards to his side effects. No more of this junk for my pups! By Tuesday evening symptoms came back worse. I finally got him to eat some chicken and he threw that up 2 hours later. Customer: Took a dose of simparica trio.second rose in second month.dog is having tremors JA: I'll do all I can to help. gave this to my dog three different times. She didn't make it to the next day and died overnight. I will not in good conscience continue to give my three previously healthy dogs anymore Simparica Trio as it causing Gand Mal seizures in my older dog and nausea , vomiting and severe thirst and dehydration. If undiagnosed he would have died. Mine is. The Trio product by Simparica is a three-in-one medication to control and prevent flea, tick, and heartworm. I'm so scared. I hate pills for me so I struggle giving this to him. I went and picked her up today and all she does is lay around and drink water, turns her nose up at anything food related. . I did find another one in New Hampshire but I know like everyone else that all we be negative just like all tests done so far. Today March 20 (8 week old) I get a message saying the puppy ate one of these pills that was for the bigger dog she already owned. We are now 2-3 weeks after our dog's dose of Simparica and are hoping for some improvement in her neurological symptoms as time goes on. Hi Charlene, can you elaborate on agitated swallowing? However, besides being nervous over the diarrhea, I am petrified about all of these people talking about seizures. Hopefully there are many other dogs that are unaffected, and just aren't written about here. I am hopeful he will make it through the next few weeks. She was terrified and we were too. What kind of supplements are you giving her? Idk what to do. but wasnt allowed in with him. Simparica Trio does cover more but after reading both I've decided to use Revolution. When fleas or ticks bite the dog, they are exposed to the drug and killed during their blood meal. We took him to a emergency Vet Hospital that pin pointed Simparica Trio as the main facture that triggered his controlled seizure episodes in having constant all day tremors & seizures hurting him to the point of making the decision to put him down or have him continue with the pain until it killed him. Over two weeks later she still can not walk properly. A week after I lost her I got COVID and was in the hospital for 20 days. Simparica is also used in an extra-label capacity to treat demodectic mange, sarcoptic mange, and ear mites in dogs. Did your dog pass away? And both of my other labs, basically house dogs, ended up with a droopy left eye. Another one of our dogs also has had several episodes of suddenly crying as if she is in great pain and also began within a week of administering the poison (please don't call this a medicine, it is a poison intended to kill fleas and other bugs and in this case it can also kill your doggie). I have been feeding her some white rice hoping it improves. He is sometimes picky with his food, so I mixed in some green beans, etc but he stopped eating anything and had bright orange diarrhea by the 31st. Again he has diarrhea and this month he seems agitated or nervous. We gave our 13 yr old lab mix this medicine as our doctor doesn't carry trifexis anymore. This sure seems like this happening way too often . Mine passed within 24 hours of the first dose. After doing more research on their monthly medication, I will no longer use Simparica Trio nor ever recommend it. I gave my morkie poo simparica trio from age 4 months until age 1 on advice of his vet. I put him on boiled chicken & rice and got him calmed down. If you accidentally ingest a pet medication, call your physician or the national Poison Control Center hotline at 800-222-1222. That was when I lived in Fort Lauderdale. My 2 1/2 mini goldendoodle has been on Simparica 10 days now. I won't sleep until we all get the justice for our babies that don't have voices of their own. I gave my six-year-old dog SIM perica because the combo guard was on back order. I had to put him laundry room for the night (no Carpet). In clinical trials, vomiting and diarrhea were the most frequently reported adverse reactions. I just want to cry! I know it's still in her system because I am still finding dead ticks that I miss because they are the size of a sesame seed. Not known if there be permanent after-effects. All they did was give me a pill in a bag with possible side effects of vomiting or diarrhea. Omg Im feeling sick seeing all these bad comments. He has been dribbling pee and no longer has a stream and for obvious reasons is asking to go out way more often than his usual. Maybe? We got to the Animal Hospital . I had always thought how can something so lethal to fleas an ticks be safe to ingest? March 2016 saw the addition of Simparica, yet another so-called Isoxazoline flea and tick "remedy" and already several dogs have been adversely affected by this new drug. Your vet should be able to answer any questions related to side effects, precautions, or special care for your dog. She had a beautiful coat of fur. This medication works within the first few hours after administration to kill fleas present on your dog, and is dosed by weight, so it is important to use the correct-sized medication for your pet. He developed these big sores which scab over quickly, hair falling out here and there. The prescription-only chewable tablet is given once a month to dogs and puppies eight weeks and older. Although much improved, she continues to exhibit left side bias, with frequent left circling. He is not the same puppy prior to two days ago! 5 hours after the dose she's home resting. Please do not use this drug. My best friend's new puppy has had diarrhea for 14 days after taking one dose of Simparica. Sadly and heartbroken I report a follow up that our healthy very active 7 yr old blue tick beagle did not make it - Frazier took his last breath on February 25 2021 - he only declined the seizures continued he was fatigued all the time started losing control of his bladder - and losing his balance and walking in circles we kept hoping that once the poison was out of him he would improve but sadly he only declined I spent many nites sitting with him because the seizures were getting so bad - we tried everything but our vet tried with us but on Feb 25th our vet said that Frazier had enough and he would not recover - I did contact the company as my vet recommended and the worst customer service reps especially in this situation all they wanted was his vet records in a very matter of fact tone as I kindly replied in southern style - kiss my biscuits!! He is also running a fever so is not out of the woods. Four months of vet visits because of one dose of field tested safe Simparica. No more of this poison for him. My dog was super sick the first months of his life. You can do this by reporting to the drugs manufacturers, who are required to report this information to the FDA, or by submitting a report directly to the FDA. I'm hoping the tremors will soon diminish, since she is in great shape otherwise. I hate that I did this to her and I hate that the Vet does not seem to care. Hes been on it for six months. My miniature Dash hound did not pull out. They want $5k to do a spinal tap and MRI. In a well-controlled laboratory study, SIMPARICA TRIO began to kill fleas at 4 hours and demonstrated 100% effectiveness at 8 hours after initial administration. I called the vet and they said it was likely brought on by stress. They were good to deal with. However a spinal tap of the fluid surrounding the spinal cord would be need to prove your dog indeed has spinal meningitis and then to treat for the specific bacterium or viral causes. My dogs have been throwing up since then and I could not for the life of me figure out why. Hi, I was just wondering how long you continued on with the steroids with your puppy. Vets have told us repeatedly that it can't be the medication. We think that the drug is the cause of the seizures . When fleas or ticks bite, they are exposed to its FDA-approved ingredient sarolaner, the insecticide, and acaricide that kills parasites fast. They still will not consider that it is the Simparica Trio. Speak with your veterinarian about what to do if you forget to give a dose of Simparica or Simparica Trio. So I started searching and came across this blog and my heart just sank. He has no appetite and very little drinking either so hes not using the bathroom much. Moreover, the safe use of this product has not been evaluated in breeding, pregnant or lactating dogs. Is due for another tablet but I have been holding off. My 1.5 yr old German Shepherd was a happy, playful healthy dog until this Poison and now I blame myself for what she is going through. Again our dog had a major seizure in January and we searched for a neurologist ear by. Gave my 14 month old 88 lb. Her protein levels dropped to almost nothing and stomach filled with fluid. I wish I would have came across this before I gave my healthy 9 month old puppy this medication two days ago. We did not make the connection until today. Mine has tremors once in a while and now I know why! Your veterinarian may recommend a heartworm test if you are using Simparica Trio. The simparica pushed his body into an Addison's Crisis - his body was literally shutting down. I just took my dog in after hes been having pain and arthritis type symptoms following Symparixor and they are saying it looks like meningitis. Does this sound familiar to anyone? Weighing your dog regularly will ensure that you are using the correct product size. Being in CT where Lyme disease is high it's a relief to have top shelf protection. She is healing and has no new rashes or sores. I am so upset - I gave it to him last week and he had an accident in the house. He had full wellness exam three ago and was in perfect shape. I am extremely upset at myself for letting a similar but very serious threat get to my pup again. I have written to the parent company that makes Simparico (although I don't hold high hopes that I will ever hear from them) and also signed an online petition at Change. Tremors continued, on and off, for 2 hours. Simparica is good at killing contagious parasites that cause mange and scabies. only 7 yrs old and I still considered a puppy b/c of how active he was, we are on 8 days now of the lethargic not eating, goopy eyes - Dr says he has hyernaited disc but I have yet to see the xrays to confirm - blood work came back normail. Thank you to all of you posting and I hope all of your babies are doing well. They keep telling me that she would have been sick from the first pill, not just the 2nd. Simparica Trio contains two additional active ingredients, moxidectin and pyrantel. its only been about 4 days since and its been a steady decline. Humans are another matter. The cardiologist found no heart condition that would cause this. Just our own personal experience but I won't get burned again! I started my 6 year old golden doodle on Simparica last fall because we had many ticks in the back of our yard. Moxidectin stops heartworm . Later in the fall I noticed some leg tremors when she squatted. Im a new pet owner and this will sound ignorant Im sure but I had NO IDEA this is how flea meds works and completely trusted my vet who knows my dogs past sensitive history and I was given the drug not even in its package so I could read anything about it but in individual pills. The vet insisted it was not from the Simparica Trio. Took her to her Vet where I was told she had another tremor. 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